Because of the pitfalls of dependancy, abuse, and misuse with opioids, even at advisable doses [see Warnings and Safeguards (five.one)], reserve promethazine HCl and codeine phosphate oral solution for use in adult individuals for whom the main advantages of cough suppression are predicted to outweigh the risks, As well as in whom an adequate evaluation of your etiology of your cough has become designed.
Greater force with your head (improved intracranial pressure). Steer clear of using Promethazine Hydrochloride and Codeine Phosphate Oral Resolution For those who have a head damage or have been instructed you have alterations within the tissue of the brain (Mind lesions) or elevated strain in the head.
On account of similar pharmacologic properties, it's sensible to anticipate similar risk with concomitant usage of opioid cough medicines and benzodiazepines, other CNS depressants, or Alcoholic beverages.
Prescription drug abuse would be the intentional non-therapeutic use of a prescription drug, even when, for its gratifying psychological or physiological consequences.
Contact neighborhood state Skilled licensing board or condition controlled substances authority for information on how to stop and detect abuse or diversion of the product.
No particular drug interaction reports are executed with promethazine HCl and codeine phosphate oral Option.
Utilize other supportive measures (which include oxygen and vasopressors) from the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Highly developed existence-support tactics. Gastric emptying may be helpful in eradicating unabsorbed drug.
The concomitant usage of promethazine HCl and codeine phosphate oral Alternative with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may well end in decreased codeine levels, better norcodeine stages, and less metabolism by using 2D6 with resultant lessen morphine degrees.
Stay clear of using promethazine HCl and codeine phosphate oral solution in sufferers having muscle mass relaxants. If concomitant use is important, monitor patients for signs of respiratory depression that may be greater than normally expected.
Daily life-threatening respiratory melancholy and Loss of life have occurred in small children who been given codeine. Almost all of the noted conditions happened adhering to tonsillectomy and/or adenoidectomy, and a lot of of the kids had evidence of being an extremely-fast metabolizer of codeine on account of a CYP2D6 polymorphism [see Warnings and Safeguards (5.three)]. Promethazine HCl and codeine phosphate oral Option is contraindicated in kids youthful than twelve yrs of age As well as in little ones young than 18 a long time of age subsequent tonsillectomy and/or adenoidectomy [see Contraindications (four)].
Postmarketing circumstances of respiratory here melancholy, including fatalities happen to be reported with usage of promethazine in pediatric people.
5.19 Neonatal Opioid Withdrawal Syndrome Promethazine HCl and codeine phosphate oral Answer isn't encouraged to be used in Expecting Women of all ages. Extended use of promethazine HCl and codeine phosphate oral Answer in the course of pregnancy may lead to withdrawal within the neonate. Neonatal opioid withdrawal syndrome, compared with opioid withdrawal syndrome in Grownups, can be everyday living-threatening if not identified and addressed, and needs administration In accordance with protocols made by neonatology professionals.
“If any individual has any Akorn merchandise in the home, call your pharmacy at the earliest opportunity and stick to up using your prescriber,” Kann stated.
Promethazine HCl and codeine phosphate oral Resolution is for oral use only. Abuse of promethazine HCl and codeine phosphate oral Answer poses a hazard of overdose and Demise.